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| Plum-colored tender plaques, palmar xanthoma and IgM gammapathy presented by Omid Zargari MD (1) and Catherine Kiavash MD (2), Rasht, Iran on December 19, 2004 (1) Assistant Professor of Dermatology (2) Resident, Department of Dermatology, Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran Abstract 1. Sweet RD. An acute febrile neutrophilic dermatosis. Br J Dermatol 1964;76:349 2. Von den Driesch P. Sweet’s syndrome (acute febrile neutrophilic dermatosis). J Am Acad Dermatol 1994;31(4):557-60 Acute febrile neutrophilic dermatosis, first described
in 1964 by Robert Douglas Sweet, has been termed Sweet's syndrome.
Classic Sweet's syndrome occurs in middle-aged women after a nonspecific
infection of the respiratory or gastrointestinal tract. Raised erythematous
plaques with pseudoblistering and occasionally pustules occur on
the face, neck, chest, and extremities, accompanied by fever and
general malaise. Involvement of the eyes, joints, and oral mucosa
as well as internal manifestations of Sweet's syndrome in the lung,
liver, kidneys, and central nervous system has been described. The
disease is thought to be a hypersensitivity reaction. Parainflammatory
(e.g., infections, autoimmune disorders, vaccination) and paraneoplastic
(e.g., hemoproliferative disorders, solid malignant tumors) occurrence
is found in approximately 25% of the cases and 2% are associated
with pregnancy. Sweet's syndrome responds rapidly to systemic therapy
with corticosteroids but recurs in about 25% of the cases. Alternative
treatment modalities (e.g., potassium iodide, colchicine, dapsone,
clofazimine, cyclosporine) have also been used. This article presents
data from 38 patients with Sweet's syndrome and reviews its epidemiology,
clinical spectrum, histologic features, laboratory results, differential
diagnosis, pathogenic mechanisms, associated diseases, and treatment. 3. Modiano P. et al. [Normolipemic plane xanthoma,
monoclonal gammopathy, anti-lipoprotein activity, hypocomplementemia] |
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